Polysaccharides are currently used for the fabrication of tridimensional networks, such as hydrogels, to be employed as substrates for cell growth and differentiation. The principal aim of the project is to evaluate how substrate mechanics would influence the differentiation of mesenchymal stem cells (MSCs). Specifically, a systematic comparison between “static” and “dynamic” systems will be considered toward cell response both in two- and three-dimensional experimental conditions.
The expected results will contribute to expand on current knowledge about extracellular matrix-to-cell interplay, whit potential translation of present materials toward regenerative medicine, including cartilage and bone tissue replacement.
As polysaccharide, this research project will consider a lactose derivative of chitosan, shortly named CTL, provided by Biopolife company located in Trieste, and now commercially available in pure medical grade. Hence, this project will exploit renewable resources obtained from waste materials to generate high added value biomedical products
Sacco, P., Cok, M., Scognamiglio, F., Pizzolitto, C., Vecchies, F., Marfoglia, A., . . . Donati, I. (2020). Glycosylated-chitosan derivatives: A systematic review. Molecules, 25(7) doi:10.3390/molecules25071534
Sacco, P., Furlani, F., Marfoglia, A., Cok, M., Pizzolitto, C., Marsich, E., & Donati, I. (2020). Temporary/Permanent dual cross-link gels formed of a bioactive lactose-modified chitosan. Macromolecular Bioscience, doi:10.1002/mabi.202000236
Pizzolitto, C., Cok, M., Asaro, F., Scognamiglio, F., Marsich, E., Lopez, F., . . . Sacco, P. (2020). On the mechanism of genipin binding to primary amines in lactose-modified chitosan at neutral pH. International Journal of Molecular Sciences, 21(18), 1-17. doi:10.3390/ijms21186831
Last updated on: 05/12/2024 - 01:10
