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Pizzolitto Chiara

Dipartimento di afferenza: 
Clinico di Scienze mediche, chirurgiche e della salute
Sede operativa: 
Università degli studi di Trieste, Ed. Q, Via Licio Giorgieri 5
Anno Corso: 
3
Settore: 
SCIENZE TECNICHE MEDICHE APPLICATE
Supervisore: 
DONATI IVAN
Titolo del progetto di ricerca: 
“Development and Characterization of 3D structures and hydrogels based on natural and modified polysaccharides for biomedical application”
Descrizione del progetto di ricerca: 

Polysaccharides are currently used for the fabrication of tridimensional networks, such as hydrogels, to be employed as substrates for cell growth and differentiation. The principal aim of the project is to evaluate how substrate mechanics would influence the differentiation of mesenchymal stem cells (MSCs). Specifically, a systematic comparison between “static” and “dynamic” systems will be considered toward cell response both in two- and three-dimensional experimental conditions.

The expected results will contribute to expand on current knowledge about extracellular matrix-to-cell interplay, whit potential translation of present materials toward regenerative medicine, including cartilage and bone tissue replacement.

As polysaccharide, this research project will consider a lactose derivative of chitosan, shortly named CTL, provided by Biopolife company located in Trieste, and now commercially available in pure medical grade. Hence, this project will exploit renewable resources obtained from waste materials to generate high added value biomedical products

Sacco, P., Cok, M., Scognamiglio, F., Pizzolitto, C., Vecchies, F., Marfoglia, A., . . . Donati, I. (2020). Glycosylated-chitosan derivatives: A systematic review. Molecules, 25(7) doi:10.3390/molecules25071534

Sacco, P., Furlani, F., Marfoglia, A., Cok, M., Pizzolitto, C., Marsich, E., & Donati, I. (2020). Temporary/Permanent dual cross-link gels formed of a bioactive lactose-modified chitosan. Macromolecular Bioscience, doi:10.1002/mabi.202000236

Pizzolitto, C., Cok, M., Asaro, F., Scognamiglio, F., Marsich, E., Lopez, F., . . . Sacco, P. (2020). On the mechanism of genipin binding to primary amines in lactose-modified chitosan at neutral pH. International Journal of Molecular Sciences, 21(18), 1-17. doi:10.3390/ijms21186831

Last updated on: 21/06/2024 - 01:10