SEMINAR DR. LUNARDI, October 2nd 2015

The paucity of therapeutic options for the treatment of sarcoma calls for a rapid and effective preclinical assessment of new therapeutic modalities. However, the regulatory circuits governing adult mesenchymal stem cells (MSCs) transformation and sarcomagenesis are still largely unknown, which substantially delays the identification of effective therapeutic approaches. Here we present a novel platform to faithful deconstruct in vitro and in vivo the molecular genetics responsible for adult MSCs-derived sarcomagenesis and, ultimately, evaluate the efficacy of targeting the identified oncopathways.