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Improving diagnosis and care in pediatric clinical immunology and rheumatology

The research group deals with translational research in the field of pediatric immunology and rheumatology. A primary focus is to participate in multidisciplinary activities to improve clinical and molecular knowledge on inborn errors of immunity. To accomplish this goal, the group integrates immunological, genomic, and transcriptomic tools to determine the clinical significance of molecular findings. Furthermore, a particular focus is laid on the possible detection of molecular targets for precision medicine and on the monitoring of the response to innovative treatments. In recent years, the group contributed to the description of the cause of novel genetic disorders and to the development of innovative treatments.

Apart from reflecting on an improved care of patients with rare immunologic disorders, the research may also impact on a deeper knowledge of the mechanisms involved in multifactorial disease, with a particular focus on rheumatological conditions like systemic lupus erythematosus, chronic non-bacterial osteomyelitis, periodic fever syndromes, Behcet’s disease. Cellular models are developed to study the interaction between diverse inflammatory pathways and the effect of pharmacologic modulation. A particular focus is on the molecularly-based patients’ stratification for a rational use of targeted treatments.

The research group works in collaboration with the local units for Oncohematology and Bone Marrow Transplantation contributing to the development of cell therapies.

The research activity can also benefit from the collaboration with other national and international research groups involved in cell immunology and clinical and molecular rheumatology.

Contacts:
Alberto Tommasini
Department of Medical Sciences
University of Trieste
✉︎ alberto.tommasini@burlo.trieste.it
ORCID
ArTS (List of Pubblications)

Last updated on: 07/29/2021 - 15:44